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RECOVERIN AND CA2+ IN VERTEBRATE PHOTOTRANSDUCTION

Hurley, James B. (1995) RECOVERIN AND CA2+ IN VERTEBRATE PHOTOTRANSDUCTION.

Short Abstract:

Recoverin is a 23 kDa Ca2+-binding protein that has been detected primarily in vertebrate photoreceptors. The role of recoverin in phototransduction has been investigated using a variety of biochemical methods. Initial reports suggesting that recoverin regulates photoreceptor guanylyl cyclase have not been confirmed. Instead, recoverin appears to determine the lifetime of light-stimulated phosphodiesterase activity perhaps by regulating rhodopsin phosphorylation. Retinal recoverin is heterogeneously fatty acylated at its amino-terminus. The amino-terminal fatty acid appears to be involved in the interaction of recoverin with photoreceptor membranes.

Long Abstract:

Recoverin is a 23 kDa Ca2+-binding protein that has been detected primarily in vertebrate photoreceptors. The role of recoverin in phototransduction has been investigated using a variety of biochemical methods. Initial reports suggesting that recoverin regulates photoreceptor guanylyl cyclase have not been confirmed. Instead, recoverin appears to determine the lifetime of light-stimulated phosphodiesterase activity perhaps by regulating rhodopsin phosphorylation. Retinal recoverin is heterogeneously fatty acylated at its amino-terminus. The amino-terminal fatty acid appears to be involved in the interaction of recoverin with photoreceptor membranes.

Keywords:	Recoverin is a 23 kDa Ca2+-binding protein that has been detected primarily in vertebrate photoreceptors. The role of recoverin in phototransduction has been investigated using a variety of biochemical methods. Initial reports suggesting that recoverin regulates photoreceptor guanylyl cyclase have not been confirmed. Instead, recoverin appears to determine the lifetime of light-stimulated phosphodiesterase activity perhaps by regulating rhodopsin phosphorylation. Retinal recoverin is heterogeneously fatty acylated at its amino-terminus. The amino-terminal fatty acid appears to be involved in the interaction of recoverin with photoreceptor membranes.
Subjects:	Neuroscience: Neuroanatomy Neuroscience: Neurochemistry Neuroscience: Neural Modelling Neuroscience: Neurology Neuroscience: Neurophysiology Psychology: Perceptual Cognitive Psychology
ID code:	bbs00000536
Deposited by:	James B Hurley on 02 May 2001