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DO THE CALMODULIN STIMULATED ADENYLYL CYCLASES PLAY A ROLE IN NEUROPLASTICITY?

Xia, Zhengui, Choi, Eui-Ju, Blazynski, Christine and Storm, Daniel (1995) DO THE CALMODULIN STIMULATED ADENYLYL CYCLASES PLAY A ROLE IN NEUROPLASTICITY?.

Short Abstract:

Evidence from invertebrate systems including Aplysia and Drosophila, as well as studies carried out with mammalian brain, have suggested that Ca2+ sensitive adenylyl cyclases may be important for long term synaptic changes and learning and memory. In addition, some forms of long term potentiation (LTP) in the hippocampus elevate cAMP signals, and activation of adenylyl cyclases and cAMP- dependent protein kinase may be required for late stages of LTP.

Long Abstract:

Evidence from invertebrate systems including Aplysia and Drosophila, as well as studies carried out with mammalian brain, have suggested that Ca2+ sensitive adenylyl cyclases may be important for long term synaptic changes and learning and memory. In addition, some forms of long term potentiation (LTP) in the hippocampus elevate cAMP signals, and activation of adenylyl cyclases and cAMP- dependent protein kinase may be required for late stages of LTP.

Keywords:	adenylyl cyclases
Subjects:	BBS Special Issues: Controversies in Neuroscience: III - Signal Transduction in the Retina and Brain Neuroscience: Neuroanatomy Neuroscience: Neurochemistry Neuroscience: Neuroendocrinology Neuroscience: Neurology Neuroscience: Neurophysiology Psychology: Psychophysics
ID code:	bbs00000454
Deposited by:	Daniel Storm on 01 May 2001